Diamine Oxidase (DAO) - Histamine Degrading Enzyme

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Diamine oxidase (DAO enzyme) is a histamine degrading enzyme that is commonly low in people with histamine intolerance, either through hindered production or genetic deficiency.

DAO is responsible for breaking down histamine in the body. If DAO levels are low, histamine will not be properly degraded, causing levels of histamine in the body to become too high and produce histamine intolerance symptoms.

DAO specifically targets histamine ingested through food or environmental exposures, therefore insufficient levels of DAO can result in reactions to histamine-containing foods, products and even contribute to seasonal allergies.

Supplementing with DAO has shown to assist with breaking down histamine in the body to reduce overall histamine levels. This process can improve symptoms for those experiencing histamine intolerance related issues.

This supplement is manufactured in the USA using only the highest quality ingredients. It is tested for potency and purity to guarantee quality and efficacy.

Suggested Use

Take 2 capsules 15 minutes before consuming meals containing histamine, or as directed by a healthcare practitioner.

Store tightly sealed in a cool, dry place.


Serving size: 2 capsules

Servings per container: 60

 Amount per serving:

Diamine Oxidase (from porcine kidney protein concentrate)

300 mcg


Other ingredients:

Capsule (Vegetable Cellulose, Microcrystalline Cellulose, Rice Flour)

 Dietary considerations:

  • Gluten Free
  • Non-GMO
  • Wheat Free
  • Dairy / Milk Free
  • Soy Free
  • Yeast Free
  • Sugar Free
  • Hydrogenated Oil Free
  • Corn Free
  • Free of Artificial Colors / Flavors

Thank you, thank you, thank you… I have been struggling with histamine intolerance for many years. I have done reading galore and have done as much research as a human can do and yours is the first real help that I have come across and am using. You are my guru.

Michelle T.

Former histamine intolerance sufferer

“Thank you again!!! I have tried many naturalists and Drs., enough to be frustrated, but your website has helped me the most so far and the protocol is bringing me back to “normal” life!”

Elena A.

Former histamine intolerance sufferer

I am so thankful to have found your website...Before I found you, I’d been pulling together an arsenal of supplements to formulate a personal protocol for treating this condition. I started having seemingly random food allergies 20 years ago and one-by-one I’ve had to eliminate foods that I love. Turns out these allergies are anything but random!

Daria R.

Former histamine intolerance sufferer

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Download the histamine intolerance food list

Included within the Low Histamine Diet guide